• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    A device for use within an occluded biological vessel and a method of using same to remove occlusion material from a vessel are provided. The device includes an elongated body configured for delivering projections arranged around a distal portion thereof into the biological vessel. Each of the projections includes a leaf-like structure connected to a stem portion having a higher axial rigidity than the leaf-like structure.
    公开号:AU2013208660A1
    申请号:U2013208660
    申请日:2013-01-15
    公开日:2014-07-24
    发明作者:Doron Jacob BEN-AMI
    申请人:TRITICUM Ltd；
    IPC主号:A61B17-22
    专利说明:
    WO 2013/105099 PCT/IL2013/050049 1 DEVICE AND METHOD FOR REMOVING OCCLUSIONS IN A BIOLOGICAL VESSEL FIELD AND BACKGROUND OF THE INVENTION 5 The present invention relates to a device for removing occlusions from a biological vessel. Specific embodiments of the present invention relate to a catheter for dislodging and collecting thrombus material from arteries and in particular brain arteries. The rapid and effective treatment of an ischemic stroke is a key factor in minimizing the morbidity and mortality that may otherwise result from this medical 10 emergency. In Ischemic stroke, thrombotic material causes occlusion of the arterial vessels that supply blood to the brain. In general, the removal of these thrombi from an occluded or partly occluded vessel may be attempted by enzymatically disintegrating the thrombus material via agents such as tissue plasminogen activator (tPA) or alteplase (thrombolysis) by administering, or by mechanically removing the thrombus 15 (thrombectomy). Two general approaches are utilized for mechanically removing thrombus material from a small blood vessel: a distal approach and a proximal approach. In the distal approach, the distal end of the retrieval device (typically fitted with a distal basket or snare) is passed through the occlusion and positioned at a distal side 20 thereof. The device is then pulled back (in a proximal direction) while the distal end engages the thrombus material. One example of a commercially-available device employing this approach is the Merci retriever, manufactured by Concentric Medical Inc. and described in US 6,663,650. In the proximal approach, the distal end of the retrieval device (fitted with a 25 grasper or an aspirator) is brought into contact with the proximal side of the thrombus and the thrombus is then pulled proximally through the vasculature and finally removed from the body. One example of a device utilizing the proximal approach is the Penumbra device, manufactured by Penumbra Inc. and disclosed in EP 1799128. Although these approaches can be used to at least partially remove thrombus 30 material occluding an artery, such removal can oftentimes be associated with an increased risk of distal emboli and the release of thrombotic debris. In addition, contact WO 2013/105099 PCT/IL2013/050049 2 of the device with the endovascular wall can cause trauma to the vascular tissues as well as precipitate vasospasm. As such, it would be highly advantageous to have a thrombus removal device capable of removing thrombus material from biological vessels and in particular brain 5 blood vessels while being devoid of the above limitations. SUMMARY OF THE INVENTION According to one aspect of the present invention there is provided a device for use within an occluded biological vessel comprising an elongated body configured for 10 delivering a plurality of projections arranged around a distal portion of the elongated body into the biological vessel, wherein each of the plurality of projections includes a leaf-like structure connected to a stem portion having a higher axial rigidity than the leaf-like structure. According to further features in preferred embodiments of the invention 15 described below, the projections are angled toward a proximal end of the elongated body. According to still further features in the described preferred embodiments the projections are capable of folding against the device body when advanced distally through an occlusion in the biological vessel. 20 According to still further features in the described preferred embodiments the stem portion may include a protrusion for increasing the axial rigidity of the stem portion. According to still further features in the described preferred embodiments the projections expand radially outward when the device is positioned within an occlusion in 25 the biological vessel and pulled in a proximal direction. According to still further features in the described preferred embodiments the stem portion of each of the projections may include a protrusion for increasing a drag force on the projections (drag forces will be created mainly by the open projections thereby facilitating radial outward expansion thereof). 30 According to still further features in the described preferred embodiments the leaf-like portion of the projections may be concave thereby enabling the leaf-lie portion to function as a scoop.
    WO 2013/105099 PCT/IL2013/050049 3 According to still further features in the described preferred embodiments the projections are arranged as single, pairs or more along the distal portion. According to still further features in the described preferred embodiments the 5 projections are connected to the elongated body via a swivel or a fixed connector or via molding. According to still further features in the described preferred embodiments the projections is fixed to the elongated body at an angle rotated 0-180 degrees from an adjacent pair of the projections. 10 According to still further features in the described preferred embodiments the elongated body and the projections are configured for positioning within a blood vessel. According to still further features in the described preferred embodiments the projections can be pushed and embedded within thrombus material when folded against the elongated body. 15 According to still further features in the described preferred embodiments the projections are capable of engaging and/or anchoring, dislodging and/or collecting the thrombus material when the projections are embedded within the thrombus and the elongated body is pulled in a proximal direction. According to still further features in the described preferred embodiments the 20 device is deliverable into the biological vessel through a 1.5-22 F sheath. According to still further features in the described preferred embodiments the leaf-like structure and the stem portion are co-molded from elastomeric material such as thermoplastic elastomers (TPEs), silicone, other plastics or metal alloys such as Nitinol or combination of materials. 25 According to still further features in the described preferred embodiments the stem portion includes an element, or structure for increasing the rigidity of the stem portion. According to still further features in the described preferred embodiments the element is a thickened region or a strut. 30 According to still further features in the described preferred embodiments the strut is a nitinol strut, thicker embodiment or enhanced structure.
    WO 2013/105099 PCT/IL2013/050049 4 According to still further features in the described preferred embodiments the leaf-like structure and the stem portion are composed of elastomeric material such as thermoplastic elastomers (TPEs), silicone, other plastics or metal alloys such as Nitinol and further wherein the stem portion is composed of a higher rigidity material, different 5 material or combination of materials. According to still further features in the described preferred embodiments the leaf-like structure of the projections includes an inward curving distal tip. According to still further features in the described preferred embodiments the inward curving distal tip is capable of hooking into the thrombus material when the 10 elongated body is pulled in a proximal direction. According to still further features in the described preferred embodiments the inward curving distal tip is configured for minimizing trauma to a wall of the biological vessel when the device is advanced distally or proximally there within. According to still further features in the described preferred embodiments the 15 device further comprises at least one imaging marker. According to still further features in the described preferred embodiments the device further comprises two imaging markers at least one of which being attached to the elongated body via an arm extending radially outward from the elongated body. According to still further features in the described preferred embodiments the 20 device further comprises a lumen extending between a distal end and a proximal portion of said device, said lumen being for enabling blood flow around an occlusion in a blood vessel. According to another aspect of the present invention there is provided a method of removing a thrombus from a blood vessel comprising: (a) positioning in the blood 25 vessel a device including a plurality of projections, each of the plurality of projections includes a leaf-like structure connected to a stem portion having a higher axial rigidity than the leaf-like structure; and (b) advancing the plurality of projections distally into a thrombus material; and (c) pulling the projections proximally to thereby penetrate, engage, dislodge and collect the thrombus material.
    WO 2013/105099 PCT/IL2013/050049 5 The present invention successfully addresses the shortcomings of the presently known configurations by providing a device for effectively and non-traumatically clearing occlusions in vessels such as blood vessels. Unless otherwise defined, all technical and scientific terms used herein have the 5 same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, suitable methods and materials are described below. In case of conflict, the patent specification, including definitions, will control. In addition, the materials, methods, and examples are 10 illustrative only and not intended to be limiting. BRIEF DESCRIPTION OF THE DRAWINGS The invention is herein described, by way of example only, with reference to the accompanying drawings. With specific reference now to the drawings in detail, it is 15 stressed that the particulars shown are by way of example and for purposes of illustrative discussion of the preferred embodiments of the present invention only, and are presented in the cause of providing what is believed to be the most useful and readily understood description of the principles and conceptual aspects of the invention. In this regard, no attempt is made to show structural details of the invention in more detail than is 20 necessary for a fundamental understanding of the invention, the description taken with the drawings making apparent to those skilled in the art how the several forms of the invention may be embodied in practice. In the drawings: FIG. 1 illustrates one embodiment of the present device. 25 FIGs. 2-3 illustrate a pair of projections in a side view (Figure 2) and an isometric view (Figure 3). FIG. 4 is a frontal view of one embodiment of the present device showing rotation offset between two pair of projections. FIGs. 5A-D schematically illustrate use of the present device in clearing an 30 occlusion from a vessel. FIGs. 6A-B illustrate various embodiments of projections which are angled with respect to the device body.
    WO 2013/105099 PCT/IL2013/050049 6 FIG. 7A illustrates an embodiment of the present device having the projections of Figure 6A. FIG. 7B illustrates an embodiment of the present device having spirally wound projections. 5 FIGs. 8A-B illustrate a prototype of the device of the present invention with reinforced (Figure 8A) and non-reinforced (Figures 8B) projections. FIGs. 9-12 illustrate bench testing of the prototypes of Figure 8A-B. DESCRIPTION OF THE PREFERRED EMBODIMENTS 10 The present invention is of a device which can be used to clear occlusions from a biological vessel. The present invention is particularly useful for unblocking occluded arteries in the brain. The principles and operation of the present invention may be better understood with reference to the drawings and accompanying descriptions. 15 Before explaining at least one embodiment of the invention in detail, it is to be understood that the invention is not limited in its application to the details set forth in the following description or exemplified by the Examples. The invention is capable of other embodiments or of being practiced or carried out in various ways. Also, it is to be understood that the phraseology and terminology employed herein is for the purpose of 20 description and should not be regarded as limiting. In order to effectively clear an occlusion from an artery, thrombus material must be effectively penetrated, engaged/anchored, dislodged and retrieved from the vessel without releasing particles into circulation and while creating minimal irritation/damage to the vessel wall. 25 In order to maximize thrombus material penetration and dislodgement, catheters having clot retrieval heads which include a plurality of discrete projections have been developed (e.g. US5895400, US7731731, US5702413, US5827304, US6350271, US6692504 or US7008434); however, such catheters may be less effective for retrieving thrombus material or minimizing damage to the vessel wall. 30 To traverse these limitations of prior art catheters and provide a catheter that is effective at penetrating, engagement, dislodging and retrieving thrombus material, the present inventor devised catheter projections which include a relatively soft leaf-like WO 2013/105099 PCT/IL2013/050049 7 structure attached to a relatively rigid stem. As is further described herein, the unique structure of the projections of the present catheter maximizes thrombus engagement, dislodgement and retrieval and minimizes trauma to the vessel wall. Thus, according to one aspect of the present invention there is provided a device 5 for removing occlusions in a biological vessel. As used herein, the phrase "biological vessel" refers to any vessel capable of supporting flow of a biological material. The vessel can be a natural vessel or a synthetic vessel implanted in a body. Examples of vessels include blood vessels such as veins or arteries, lymphatic vessels, urinary system vessels such as the urethra or ureters, seminal vessels, saliva ducts, bile ducts and more. 10 Occlusions are any flow limiting blockages in the vessel which are caused by local buildup of atherosclerotic material, atherosclerotic emboli, migrating blood clots, biological stones or the like. The device includes an elongated body for delivering a plurality of projections arranged around a distal portion of the elongated body into the biological vessel. The 15 device can be configured as a catheter for use with a guidewire in clearing thrombus material from a blood vessel. When configured as a catheter, the elongated body can include a longitudinal lumen sized for accepting a guidewire (e.g. 0.014", 0.018" or 0.035" or other guidewires). The lumen can be configured for use with over-the-wire, or rapid exchange systems. 20 The device can also be delivered within a hollow catheter/delivery tube (guiding catheter). In such cases, the catheter/delivery tube is positioned using a guidewire which is then removed to allow positioning of the present device. The elongated body can be 10 to 200 cm in length with a width/diameter of 0.5-7 mm when in closed configuration (suitable for delivery within a 1.5-22 F sheath). The 25 elongated body is preferably shaped as shaft (rod or tube) and is fabricated from any bio compatible material, including, for example, alloys such as stainless steel, Nitinol or polymers such as Polyimide (PI), Polyether Block Amide (PEBA) - Pebax. The elongated body is preferably axially rigid in order to facilitate lodging of the distal portion (carrying the projections) into the occlusion and yet flexible enough to facilitate 30 navigation through torturous vessels while ensuring safety (e.g. blood vessels in the brain). Rigidity of the elongated body (catheter) is same range as catheters commonly used for navigating biological vessels such as blood vessels.
    WO 2013/105099 PCT/IL2013/050049 8 Each projection includes a leaf-like structure connected to a stem portion having a higher axial rigidity than the leaf-like structure. Any number of projections can be carried on the elongated body depending on the biological vessel, occlusion size and type and function of the device. A typical number of projections can range from 1-20 or 5 more. The stem portions connect the leaf-like structures to the elongated body and are oriented such that leaf-like structures project radially outward and backwards from the elongated body at an angle of 0-90, degrees or above with respect to the longitudinal axis of the elongated body. 10 The axial rigidity of the stem portion can be preferably anywhere from 0.1 - 100 grams (e.g. 10-90, 20-80, 30-70, 40-60) or more depending on the occlusion location, occlusion type and size, leaf like structure and material the stem is constructed from. The axial rigidity of the leaf like structures can preferably be anywhere from 0.0 - 50 grams (e.g. 5-40, 10-30, 20-25) or more depending on the occlusion location, occlusion 15 type and size, leaf like structure and material the leaf is constructed from. The leaf-like structures and optionally stems are preferably elastically deformable made out of elastomeric material such as thermoplastic elastomers (TPEs), silicone, other plastics or metal alloys such as Nitinol. Elasticity is selected such that when the device is advanced distally into an occlusion (thrombus) within the biological 20 vessel, the projections fold against the elongated body due to the forces exerted by the occlusion/thrombus mass. This enables the projections to penetrate an occlusion (e.g. thrombus) in the vessel without crossing or deploying distally outside to the thrombus mass and lodge therein. When the device is pulled in a proximal direction, the projections deploy outward (to the angle set by the stems or the vessel wall limitation) 25 due to the drag forces exerted by the occlusion (thrombus) mass thereby enabling the device to engage/anchor to the occlusion material, dislodge it from the vessel wall and remove it. The leaf-like structure can be of any shape and size suitable for collection of occlusion material. The leaf-like structures can be oval-shaped, 30 rectangular/polyangular-shaped, spiral, a combination of several shapes including simple or complex shapes with fractal characteristics.
    WO 2013/105099 PCT/IL2013/050049 9 Typical dimensions for the leaf-like projections can be 0.2 - 30 millimeter in length, 0.05-20 millimeter in width, 0.03-3 millimeter in thickness, with a single side surface 2 area of 0.01-600 millimeters The stems portions can be 0.1-20 millimeter in length, 0.02-20 millimeter in 5 width, 0.03-3 millimeter in thickness. The internal surface (facing towards the elongated body) of the leaf-like structure is preferably concave in order to increase the surface area thereof and the drag/resistance force exerted on the internal surface by the thrombus mass. Such a concave configuration also increases the ability of the projections to collect (scoop) the occlusion 10 material. The exterior surface of the leaf-like structure is preferably convex to facilitate delivery within the vessel and lodging of the projections into the occlusion while folded in a "close configuration" (arrow like) due to the drag forces exerted on the leaves-like by the occlusion material when the projections are advanced into the occlusion. Although such a configuration is preferred, internal and external surfaces having 15 alternative contours (e.g. flat on both sides) are also envisaged herein. Each leaf-like structure can also fold in half lengthwise to further improve penetration into the occlusion material. Folding of the projections and the leaf-like structures occurs during use, in accordance with the mechanical forces exerted upon the projections and the leaf-like 20 portions thereof by the occlusion material and the vessel wall. The internal surface of the leaf-like structures can also include projections (micrometers to millimeters in height) to increase the surface area and enhance interaction between the leaf-like structures and the occlusion material. Such projections can be simple protrusions or branching, "fractal-like" protrusions which significantly 25 increases the surface area in contact with the thrombus material. This can improve a one-piece retrieval of the thrombus in a shape and size similar to its previous in situ form and minimizing the risk of embolism as a result of particles "escaping" from the thrombotic mass. The distal portion (tip) of the leaf-like structure is preferably curved inward in 30 order to minimize trauma/damage to the vessel when the device is navigated within the blood vessels. To further decrease trauma and irritation to the vessel wall, the tips can be fabricated from a very soft material (softer than the rest of the leaf-like structure).
    WO 2013/105099 PCT/IL2013/050049 10 The inward curving tips can also facilitate hooking of the projections into the occlusion material. The unique configuration of projections of the present device provides several advantages in clearing occlusions in a biological vessel. 5 (i) Delivery and penetration of occlusion material - when the present device is advanced in a distal direction the contour of the external surface and elasticity of the leaf-like structures enable folding of the projections which reduces the profile of the device and also streamlines the outer surface of the folded projections. This enhances delivery and minimizes disruption of the occlusion (which can lead to release of embolic 10 particles). (ii) Engagement/anchoring of occlusion material - when the present device is pulled in a proximal direction, drag forces are applied to the inner surfaces of the leaf like structures and cause the projections to open. This increases the cross sectional area of the device and its surface interaction with the occlusion. In addition, exposure of the 15 inward curving tips to the occlusion material, increases penetration and lodging of the projections in the occlusion material. The stem portion prevents the projections from flipping over thereby ensuring that a pulling force at the handle/proximal part of the device is efficiently converted to engagement/anchoring force. (iii) Dislodgement of occlusion material - the pulling force at the 20 handle/proximal part of the catheter is also efficiently converted to a proximal movement of the catheter-occlusion complex. The projections can be designed such that the forces applied thereby are matched to the type and location of occlusion. The forces applied by the projections on the occlusion are a function of the occlusion material, size and the properties of the occlusion and the vessel surrounding it, thus minimizing 25 unnecessary force and distortion of the thrombus natural configuration. (iv) Removal of occlusion - the increased surface area, and the multiple contact areas (at plurality of projections), as well as the unique scoop-like shape of the internal surface of the leaf-like structures facilitate collection of dislodged material. The occlusion material is trapped by the device (projections) creating a catheter-thrombus 30 complex that can be removed as one piece. The present invention is described in greater detail hereinbelow with reference to the embodiment shown in Figures 1-4.
    WO 2013/105099 PCT/IL2013/050049 11 Referring now to the drawings, Figures 1-4 illustrate one embodiment of the present invention which is referred to herein as device 10. Device 10 is configured suitable for entering, engaging/anchoring, dislodging and collecting thrombus material from a blood vessel and in particular small blood 5 vessels of the brain. Device 10 includes an elongated body 12 having a handle 14 (user engaged portion) at proximal end 16 and projections 18 (12 shown) attached to a distal portion 20. Elongated body 12 includes a nose cone 30 for facilitating non-traumatic delivery into a vessel and also allows penetration into the occlusion/thrombus. 10 Projections 18 are preferably arranged as single or pairs (arrangements including 3, 4, 5, 6 or more projections are also possible) around distal portion 20, with each single or pair rotated 0 - 180 degrees from an adjacent single pair. Figure 4 is a frontal view of device 10 showing two pairs of projections 18 arranged with a 90 degree rotational offset between pairs. 15 Figures 2-3 illustrate one pair of projections 18 in greater detail. Each projection 18 includes a stem portion 22 which is attached to a leaf-like structure 24. As is mentioned hereinabove, the axial rigidity of stem portion 22 is greater than that of leaf-like structure 24. Such increased axial rigidity can be achieved by fabricating stem portion 22 from a more rigid material, by making stem portion 22 thicker than leaf 20 structure 24 or by providing stem portion 22 with a rigidifying strut (e.g. Nitinol/stainless steel strut co-molded with stem portion 22). In the embodiment shown in Figures 1-4, stem portion 22 includes a thickened portion 26 which serves to both increase rigidity thereof and limit the angle of stem portion 22 with respect to the longitudinal axis of elongated body 12, such that outward deployment of projections 18 25 is limited to a preset angle a (Figure 2) set by portion 26. Portion 26 is also rigid enough to prevent projections 18 from flipping over (angling towards the distal direction). As is shown in Figures 2-3, leaf-like structure 24 includes an inward curving tip 34 for minimizing damage or irritation to the vessel wall when device 10 is pushed and 30 pulled within the vessel. Inward curving tip 34 also functions to facilitate lodging of projections 18 into occlusion material (e.g. thrombus material) when device 10 is pulled in a proximal direction.
    WO 2013/105099 PCT/IL2013/050049 12 As is shown in greater detail in Figure 3, leaf-like structures 24 are preferably concave (C) at an internal surface thereof and convex (X) on the opposite surface. When in proximal movement after engaged to the thrombus mass the concave shape of the inner surface allows a higher surface contact area and higher drag forces. In addition, 5 leaf-like structure 24 scoops the occlusion material dislodged from the vessel wall. When moving distally and penetrating the thrombus mass the convex shape produces less drag forces. The concave shape also allows projections 18 to fold into a compact streamlined configuration for delivery into the vessel and occlusion. Additional hydrodynamic streamlining of projections 18 may be effected by providing the outer 10 surface thereof with one or more bumps/protrusions/channels etc. Projections 18 can be individually attached to elongated body 12 via gluing or mechanical couplers. Preferably, projections 18 are attached to elongated body 12 via a fixed or swivel coupler or via molding. For example, two stem portion 22 can be co-molded with a cylindrical coupler 32 (Figure 3) which can be fitted around elongated body 12 and 15 fixedly attached thereto or allowed to swivel. Leaf-like projections can then be glued or mechanically coupled to the distal end of stem portions 22 - or just molded as one piece from the same material. Projections 18 can be fabricated from a single material or from two or more materials. For example, in the embodiment shown in Figures 1-4, projections can be 20 molded from a single material (e.g. silicone, teflon, nylon and any other elastomer, metal alloys such as Nitinol or elastomer with combination with metal alloys such as Nitinol), with the differential rigidity provided by varying the durometer of the material (e.g. molding stem portion 22 from a different structure, a silicone having a higher Shore A value or increased thickness, or by using a different material or a combination of 25 different materials). Device 10 can further include a web like element interposed between projections 18. Such an element can supplement the ability of device 10 to capture/harvest dislodged occlusion material. As is mentioned hereinabove, the embodiment of device 10 of Figures 1-4 is 30 configured for use in clearing obstructions in a blood vessel, preferably a small brain artery that is 0.5-7 millimeter in diameter. As such, elongated body 12 of device 10 is preferably 10-200 centimeter in length, 0.5-7 millimeter in diameter when in closed WO 2013/105099 PCT/IL2013/050049 13 configuration, while projections 18 are preferably 0.2-30 mm in length. The length of leaf-like structures is preferably 0.1-30 mm and the width (at the widest thereof) is preferably 0.05-20 mm. Stem portion 22 is preferably 0.1-20 mm in length and 0.02-20 mm in width (at the base). 5 Projections 18 can be folded against elongated body 12 to an overall diameter of 0.5-7 millimeter. When folded, device 10 can be packed into a 1.5-22 F sheath for delivery through an access site. Once pushed out of the sheath, projections 18 are folded outward to a position constrained by stem portion 22 (or vessel wall) while distal portion 20 is advanced to the site of occlusion. Since leaf-like structure 24 includes a non 10 traumatic tip 34, advancing device 10 in the distal direction (towards occlusion) does not traumatize or irritate the vessel wall. Once in position, pulling on handle/proximal catheter part 14 deploys projections 18 to angle a as limited by stem portions 22 or the vessel wall. In the deployed position, leaf structures 24 are displaced up to 90 degrees (or more) from the longitudinal axis of elongated body 12 (as limited by stem portion 15 22) to nearly contact or contact the wall with tip 34 angling inward to eliminate trauma and irritation to vessel wall. The flexible nature of the leaves-like permits the device to automatically adapt to the caliber of the blood vessel in which device 10 is situated Stem portion 22 and/or leaf-like structure 24 can also be configured such that 20 when folded against elongated body 12, the longitudinal axis of leaf like structure 24 is angled with respect to the longitudinal axis of elongated body 12 (Figures 6a-b). This increases the exposure of the internal surface to the biological fluid in the vessel and to the occlusion material and increases drag and likelihood of deployment when device 10 is pulled in a proximal direction. 25 Figures 6a-b illustrate alternative angulations of projections 18. As is shown in Figure 6a, projections 18 can be angled laterally (angle range 0-90 degrees) relative to the device main long axis (yaw). This will prevent full symmetry and overlapping of the leaves when in closed configuration and in backward (proximal) movement. The lack of symmetry exposes the inner surface area of leaf-like structures 24 to the occlusion to 30 initiate opening of projections 18. A device 10 having such projections 18 is shown in Figure 7a.
    WO 2013/105099 PCT/IL2013/050049 14 A roll angle can also be added such that each leaf-like structure 24 has an "angle of attack" (Figure 6b) relative to the movement vector (angle range 0-90 degrees) i.e. to the anterior edge of leaf-like structures 24 relative to movement of device 10. The angle of attack in the forward motion (when device 10 is pushed towards occlusion) will have 5 hydrodynamic features and a curve design that will ensure an ability to optimally penetrate and minimally disrupt the thrombus structure. When the device is pulled proximally, the angle of attack (which is the opposite edge) can be shaped in a more acute curve structure in order to allow optimal drag forces of the thrombus on each leaf-like structure 24 thereby ensuring opening of projections 18. 10 Projections 18 can also be configured to spiral around elongated body 12 as is shown in the example of Figure 7b. The size shape and properties of projections 18 can be configured according to the blood vessel and occlusion properties. There are two type of thrombus occlusions, a 'red' thrombus (fresh, acute whole blood thrombus) and a 'white' thrombus (relatively 15 chronic embedded with cholesterol and calcium). Projections 18 of device 10 have rigidity properties at a range matching the viscosity ranges of the thrombus. When configured as a catheter, device 10 includes a lumen 35 which terminates at opening 36. Lumen 35 is configured for accepting a guidewire for guiding device 10 to a target occlusion within a vessel. Lumen 35 can traverse the entire length of 20 elongated body 12 (when use with an over-the-wire system) to an guidewire inlet opening in a proximal end of elongated body or alternatively, lumen 35 can traverse a portion thereof (when used with a rapid exchange system) to a guidewire inlet opening at a side wall along a length of elongated body 12. Lumen 35 can also include one or more holes or other opening along a portion of 25 elongated body proximal to projections 18. Such holes can be in fluid communication with an opening at tip 30 and would thus enable blood to flow around the occlusion mass once projections 18 penetrate the occlusion and tip 30 crosses the occlusion and is positioned at its distal side. This will allow reperfusion of the ischemic brain tissue located distally to the 30 occlusion site. The relatively low flow of blood (through the catheter) provides controlled low flow, low pressure reperfusion to the Penumbra brain tissue which is at a metabolic "shutdown" state and thus might be vulnerable to high pressure systolic blood WO 2013/105099 PCT/IL2013/050049 15 flow. This will prepare the tissue for restoration of full flow following removal of the thrombus. In cases where delivery is effected through a catheter or guide tube (guiding catheter), delivery and navigation of device 10 can be effected without a guidewire. 5 In any case, handle 14 (or proximal portion of elongated body 12) is used to guide device 10 (whether over a wire or not) through the vessel and position distal portion 20 at a site of occlusion. Use of device 10 in clearing a thrombus in a blood vessel is described in greater detail below with reference to Figures 5a-d. 10 Device 10 can also include radio-opaque markers (e.g. gold, platinum, iridium or combined with the polymer itself or other radio-opaque markers) mounted on the distal end of elongated body 12 (near tip 30). The markers can be mounted on ends of foldable arms (e.g. Nitinol, platinum, other metal alloy or polymer wires) extending radially outward from elongated body 12. 15 When distal portion 20 is positioned outside of the occlusion, the markers arms extend out and thus when visualized (fluoroscopy) the markers are a predetermined distance apart (e.g. several millimeters). When distal portion 20 is positioned inside an occlusion, the markers arms fold against elongated body 12 and thus when visualized (fluoroscopy) the distance between the markers is reduced. 20 Alternatively, one of the markers can be mounted on a foldable arm extending radially outward from elongated body 12, while the second marker can be attached to elongated body 12. When distal portion 20 is positioned inside an occlusion, the marker arm is folded against elongated body 12 and brought into proximity to the second marker. The distance between the markers can be visualized (fluoroscopy) to determine 25 the extent of folding of the arm. Still alternatively, one or more markers can be fixed to one or more tips 30, such that when distal portion 20 is positioned within an occlusion, folding of projection(s) 18 carrying the marker can be used to determine a distance between tip 30 and elongated body 12 or between a pair of tips 30. 30 Marker material (e.g. iridium or platinum) can also be included in the material used to fabricate projections 18 or leaf-like structures 24 in order to facilitate identification thereof by a surgeon.
    WO 2013/105099 PCT/IL2013/050049 16 In any case, the markers assist the clinician in determining the correct placement of device 10 within a blood vessel and indicate when distal portion 20 enters an occlusion and projections 18 are lodged therein. In order to increase the ability of leaf-like structures 24 to collect occlusion 5 material, the internal surface thereof can be coated with a substance that can bind the occlusion material. For example, in the case of a thrombus occlusion, the internal surface of leaf-like structure 24 can be coated with fibrin. Device 10 of the present invention can be used to clear any type of occlusion in any vessel. Figures 5a-d illustrate use of device 10 in clearing a thrombus in an artery. 10 A guide catheter or guidewire is advanced from an access site (e.g. in a femoral artery) to the carotid artery under angiography. Device 10 is then inserted over-the-wire or through the guide catheter and navigated to the site of the thrombus (Figure 5a). The surgeon then advances the distal end of device 10 into the thrombus (Figure 5b) until the distal end of device 10 reaches the distal end of the thrombus (as visualized via the 15 radio-opaque markers described above). The surgeon then applies a gentle pulling force on device 10 to open projections 18 and lodge and engage/anchor them within the thrombus. The device is then pulled along with the trapped thrombus (Figure 5c). As used herein the term "about" refers to ± 10 %. 20 Additional objects, advantages, and novel features of the present invention will become apparent to one ordinarily skilled in the art upon examination of the following examples, which are not intended to be limiting. 25 EXAMPLES Reference is now made to the following example, which together with the above descriptions, illustrate the invention in a non limiting fashion. Bench testing of a prototype 30 Several prototypes of the device of the present invention were constructed by mounting 4 pairs of 30 mm long and 8 mm wide silicone projections (10 mm stem portion and 20 mm leaf like structure) on a stainless-still rod 1 millimeter in diameter. Two types of projections were tested, 'soft' projections fabricated from 70 Shore silicone WO 2013/105099 PCT/IL2013/050049 17 (Figure 8b) and reinforced projections fabricated from 70 Shore silicone and including a 20 mm plastic strut fixed to the stem portion and a portion of the leaf-like structure of each projection (Figure 8a). Two configurations of projections were tested, pairs arranged with a 90 degree rotational offsets, and pairs arranged with a 45 degree 5 rotational offset. The total diameter of the device was 25 mm when the projections were in the open configuration (Figure 8a) and 10 mm when in the closed configuration (Figure 8b) The device prototypes were tested for the ability to remove a blood clot from a tube. 10 Fresh human venous blood was drawn from cubital fossa vein and was mixed for 10 seconds with human thrombin (BioPharm Laboratories, LLC, Bluffdale, Utah, USA) at a ratio of 25 IU to 10 ML whole blood and was incubated for 60 minutes at room temperature inside cylindrical transparent tubes having the following dimensions: (i) Length: 100 millimeter; internal diameter: 25 millimeter 15 (ii) Length: 100 millimeter; internal diameter: 20 millimeter The resulting blood clot had the following dimensions: (i) Length: 40 millimeter; diameter of 25 millimeter (ii) Length: 60 millimeter; diameter of 20 millimeter 20 In total, 6 clot occlusions were prepared (3 in each of the tubes described above). Each device prototype (Figure 9) was advanced into the tube to penetrate the proximal clot mass until the distal tip of the device reached the distal (end) of the clot 25 mass (Figure 10). In total, 6 clot penetrations were conducted: (i) four with the "enforced" catheter prototype: 3 x 25 millimeter thrombus diameter and 1 x 20 millimeter thrombus diameter; and (ii) two with the "soft" catheter prototype: 2 x 20 millimeter thrombus diameter 30 It was observed that while penetrating the clot mass, the projections folded into a closely packed configuration (Figure 11).
    WO 2013/105099 PCT/IL2013/050049 18 The device prototypes were then pulled in the proximal direction dislodging the clot mass and collecting it out of the tube (Figure 12). It was observed that movement of the device in the proximal direction opened the projections outward from the central rod thereby facilitating scooping of the clot 5 material. In all 6 tests (two types of tubes, two device prototypes) the device prototypes collected the entire clot mass in one pass. It is appreciated that certain features of the invention, which are, for clarity, 10 described in the context of separate embodiments, may also be provided in combination in a single embodiment. Conversely, various features of the invention, which are, for brevity, described in the context of a single embodiment, may also be provided separately or in any suitable subcombination. 15 Although the invention has been described in conjunction with specific embodiments thereof, it is evident that many alternatives, modifications and variations will be apparent to those skilled in the art. Accordingly, it is intended to embrace all such alternatives, modifications and variations that fall within the spirit and broad scope of the appended claims. All publications, patents and patent applications mentioned in 20 this specification are herein incorporated in their entirety by reference into the specification, to the same extent as if each individual publication, patent or patent application was specifically and individually indicated to be incorporated herein by reference. In addition, citation or identification of any reference in this application shall not be construed as an admission that such reference is available as prior art to the 25 present invention.
    权利要求:
    Claims (26)
    [1] 1. A device for use within an occluded biological vessel comprising an elongated body configured for delivering a plurality of projections arranged around a distal portion of said elongated body into the biological vessel, wherein each of said plurality of projections includes a leaf-like structure connected to a stem portion having a higher axial rigidity than said leaf-like structure.
    [2] 2. The device of claim 1, wherein said projections are angled toward a proximal end of said elongated body.
    [3] 3. The device of claim 1, wherein said projections are capable of folding against said device body when advanced distally through an occlusion in the biological vessel.
    [4] 4. The device of claim 1, wherein said stem portion includes a protrusion for increasing said axial rigidity of said stem portion.
    [5] 5. The device of claim 1, wherein said projections expand radially outward when the device is positioned within an occlusion in the biological vessel and pulled in a proximal direction.
    [6] 6. The device of claim 5, wherein said stem portion of each of said projections includes a protrusion for increasing a drag force on said projections (drag forces will be created mainly by the open projections thereby facilitating radial outward expansion thereof).
    [7] 7. The device of claim 1, wherein said leaf-like portion of said projections is concave thereby enabling said leaf-lie portion to function as a scoop.
    [8] 8. The device of claim 1, wherein said projections are arranged as pairs along said distal portion. WO 2013/105099 PCT/IL2013/050049 20
    [9] 9. The device of claim 8, wherein each pair of said projection is connected to said elongated body via a swivel.
    [10] 10. The device of claim 8, wherein each pair of said projections is fixed to said elongated body at an angle rotated 0-90 degrees from an adjacent pair of said projections.
    [11] 11. The device of claim 1, wherein said elongated body and said projections are configured for positioning within a blood vessel.
    [12] 12. The device of claim 11, wherein said projections can be pushed and embedded within thrombus material when folded against said elongated body.
    [13] 13. The device of claim 12, wherein said projections are capable of dislodging and/or collecting said thrombus material when said projections are embedded within said thrombus and said elongated body is pulled in a proximal direction.
    [14] 14. The device of claim 1, wherein the device is deliverable into the biological vessel through a 3-8 F sheath.
    [15] 15. The device of claim 1, wherein said leaf-like structure and said stem portion are co-molded from silicone.
    [16] 16. The device of claim 1, wherein said stem portion includes an element for increasing said rigidity of said stem portion.
    [17] 17. The device of claim 16, wherein said element is a thickened region or a strut.
    [18] 18. The device of claim 17, wherein said strut is a nitinol strut. WO 2013/105099 PCT/IL2013/050049 21
    [19] 19. The device of claim 1, wherein said leaf-like structure and said stem portion are composed of silicone and further wherein said stem portion is composed of a higher Shore silicone.
    [20] 20. The device of claim 1, wherein said leaf-like structure of said projections includes an inward curving distal tip.
    [21] 21. The device of claim 20, wherein said inward curving distal tip is capable of hooking into said thrombus material when said elongated body is pulled in a proximal direction.
    [22] 22. The device of claim 20, wherein said inward curving distal tip is configured for minimizing trauma to a wall of the biological vessel when the device is advanced distally therewithin.
    [23] 23. The device of claim 1, further comprising at least one imaging marker.
    [24] 24. The device of claim 1, further comprising two imaging markers at least one of which being attached to said elongated body via an arm extending radially outward from said elongated body.
    [25] 25. The device of claim 1, further comprising a lumen extending between a distal end and a proximal portion of the device, said lumen being for enabling blood flow around an occlusion in a blood vessel when the device is positioned in said blood vessel with said distal portion within said occlusion.
    [26] 26. A method of removing a thrombus from a blood vessel comprising: (a) positioning in the blood vessel a device including a plurality of projections, each of said plurality of projections includes a leaf-like structure connected to a stem portion having a higher axial rigidity than said leaf-like structure; and WO 2013/105099 PCT/IL2013/050049 22 (b) advancing said plurality of projections distally into a thrombus material; and (c) pulling said projections proximally to thereby penetrate, dislodge and collect said thrombus material.
    类似技术:
    公开号 | 公开日 | 专利标题
    AU2013208660B2|2016-12-08|Device and method for removing occlusions in a biological vessel
    US10799331B2|2020-10-13|System for removing a thrombus from a blood vessel
    CN107920827B|2021-06-01|Axially elongated thrombus capture system
    US7713227B2|2010-05-11|Method and apparatus for medical device for aspiration of thromboemobolic debris
    EP3579765A1|2019-12-18|Axial lengthening thrombus capture system
    US10772647B2|2020-09-15|Device and method for removing occlusions in a biological vessel
    US20220000506A1|2022-01-06|Method for treating vascular occlusion
    US20220000505A1|2022-01-06|Method for treating vascular occlusion
    US20220000507A1|2022-01-06|Method for treating vascular occlusion
    同族专利:
    公开号 | 公开日
    JP2015506229A|2015-03-02|
    JP2018122123A|2018-08-09|
    EP2804547B1|2018-04-04|
    IL233660A|2018-08-30|
    IL233660D0|2014-08-31|
    AU2013208660B2|2016-12-08|
    WO2013105099A2|2013-07-18|
    CN104093369B|2017-03-01|
    EP2804547A4|2015-06-10|
    US10786268B2|2020-09-29|
    CA2860301C|2019-04-23|
    CN104093369A|2014-10-08|
    MX2014008474A|2015-07-17|
    US9987027B2|2018-06-05|
    CN105943117A|2016-09-21|
    JP6430674B2|2018-11-28|
    US20180235645A1|2018-08-23|
    JP6363957B2|2018-07-25|
    ES2671045T3|2018-06-04|
    CA2860301A1|2013-07-18|
    EP2804547A2|2014-11-26|
    US20140309657A1|2014-10-16|
    WO2013105099A3|2013-10-10|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US4643184A|1982-09-29|1987-02-17|Mobin Uddin Kazi|Embolus trap|
    US4765332A|1986-07-14|1988-08-23|Medinnovations, Inc.|Pullback atherectomy catheter system|
    FR2617720A1|1987-07-08|1989-01-13|Medipro|DEVICE FOR DESOBSTRUCTING INTUBATION PROBES AND IN VIVO TRACHEOTOMY CANNULAS|
    US5009659A|1989-10-30|1991-04-23|Schneider Inc.|Fiber tip atherectomy catheter|
    GB2238485B|1989-11-28|1993-07-14|Cook William Europ|A collapsible filter for introduction in a blood vessel of a patient|
    US5421832A|1989-12-13|1995-06-06|Lefebvre; Jean-Marie|Filter-catheter and method of manufacturing same|
    US5192290A|1990-08-29|1993-03-09|Applied Medical Resources, Inc.|Embolectomy catheter|
    US5129910A|1991-07-26|1992-07-14|The Regents Of The University Of California|Stone expulsion stent|
    CH685738A5|1993-03-25|1995-09-29|Ferromec Sa|Medical instrument for removing deposits formed on the inner walls of the arteries or veins.|
    WO1994023787A1|1993-04-22|1994-10-27|Rammler David H|Sampling balloon catheter|
    US5370653A|1993-07-22|1994-12-06|Micro Therapeutics, Inc.|Thrombectomy method and apparatus|
    US5769960A|1995-07-05|1998-06-23|Nirmel; Chittaranjan N.|Device and method for manually removing a clog containing fibrous matter|
    JP2000504594A|1996-02-02|2000-04-18|トランスバスキュラーインコーポレイテッド|Method and apparatus for blocking flow in a blood vessel|
    US5827304A|1995-11-16|1998-10-27|Applied Medical Resources Corporation|Intraluminal extraction catheter|
    US5702413A|1996-01-11|1997-12-30|Scimed Life Systems, Inc.|Curved bristle atherectomy device and method|
    US6254571B1|1996-04-18|2001-07-03|Applied Medical Resources Corporation|Remote clot management|
    US5882329A|1997-02-12|1999-03-16|Prolifix Medical, Inc.|Apparatus and method for removing stenotic material from stents|
    US5895400A|1997-06-27|1999-04-20|Abela; George S.|Catheter with bristles|
    US5984965A|1997-08-28|1999-11-16|Urosurge, Inc.|Anti-reflux reinforced stent|
    US5836032A|1997-09-30|1998-11-17|Hondo; Leslie H.|Apparatus for removing hair from a drain|
    US6027514A|1997-12-17|2000-02-22|Fox Hollow Technologies, Inc.|Apparatus and method for removing occluding material from body lumens|
    US6725492B2|1998-11-25|2004-04-27|Neosci Medical, Inc.|Cleaning brush for medical devices|
    US6350271B1|1999-05-17|2002-02-26|Micrus Corporation|Clot retrieval device|
    US6458139B1|1999-06-21|2002-10-01|Endovascular Technologies, Inc.|Filter/emboli extractor for use in variable sized blood vessels|
    US6775873B2|2000-02-09|2004-08-17|Eugene H. Luoma|Apparatus for removing hair from a drain|
    USD435944S1|2000-02-09|2001-01-02|Eugene H. Luoma|Drain cleaner strip|
    US8298257B2|2000-06-29|2012-10-30|Concentric Medical, Inc.|Systems, methods and devices for removing obstructions from a blood vessel|
    US7727242B2|2000-06-29|2010-06-01|Concentric Medical, Inc.|Systems, methods and devices for removing obstructions from a blood vessel|
    CN100382859C|2001-01-09|2008-04-23|微温森公司|Embolectomy catheters and method for treatment|
    US6800083B2|2001-04-09|2004-10-05|Scimed Life Systems, Inc.|Compressible atherectomy burr|
    JP4567918B2|2001-07-02|2010-10-27|テルモ株式会社|Intravascular foreign matter removal wire and medical device|
    JP2003038500A|2001-08-03|2003-02-12|Mti Kk|Shaft with brush for foreign matter removal in tubular organ|
    US20040215222A1|2003-04-25|2004-10-28|Michael Krivoruchko|Intravascular material removal device|
    US20070118165A1|2004-03-08|2007-05-24|Demello Jonathan R|System and method for removal of material from a blood vessel using a small diameter catheter|
    DE602005013074D1|2004-03-31|2009-04-16|Orthofix Srl|BRAND NAIL WITH ELEMENTS OF MOLDED MEMORY|
    IL161554D0|2004-04-22|2004-09-27|Gali Tech Ltd|Catheter|
    US8241315B2|2004-06-24|2012-08-14|Boston Scientific Scimed, Inc.|Apparatus and method for treating occluded vasculature|
    DE102004040868A1|2004-08-23|2006-03-09|Miloslavski, Elina|Device for removing thrombi|
    US20150164630A1|2008-01-04|2015-06-18|Eric Johnson|Filter support members|
    EP1848348A2|2005-02-02|2007-10-31|Peacock, James C., III|Total vascular occlusion treatment system and method|
    US20060184194A1|2005-02-15|2006-08-17|Cook Incorporated|Embolic protection device|
    USD532978S1|2005-02-16|2006-12-05|Marie Robinson|Flexible compressible brush for cleaning drinking straws|
    US7731731B2|2005-06-17|2010-06-08|Abela George S|Catheter for clearing passages in a patient|
    US8734362B2|2005-07-26|2014-05-27|Edward M. Boyle, JR.|Minimally invasive methods and apparatus|
    US8377092B2|2005-09-16|2013-02-19|Cook Medical Technologies Llc|Embolic protection device|
    US7914549B2|2007-01-05|2011-03-29|Hesham Morsi|Mechanical embolectomy and suction catheter|
    US9138307B2|2007-09-14|2015-09-22|Cook Medical Technologies Llc|Expandable device for treatment of a stricture in a body vessel|
    US8021379B2|2008-01-11|2011-09-20|Medtronic Vascular, Inc.|Obstruction removal system|
    US8021380B2|2008-01-11|2011-09-20|Dustin Thompson|Obstruction removal system|
    GB2459481A|2008-04-23|2009-10-28|Invivo Technology Ltd|Expanding medical collet|
    US8939991B2|2008-06-08|2015-01-27|Hotspur Technologies, Inc.|Apparatus and methods for removing obstructive material from body lumens|
    WO2010017537A2|2008-08-08|2010-02-11|Incept, Llc|Apparatus and methods for accessing and removing material from body lumens|
    US8034095B2|2008-08-29|2011-10-11|Cook Medical Technologies Llc|Intraluminal system for retrieving an implantable medical device|
    US20100249815A1|2009-03-25|2010-09-30|Cook Incorporated|Everted sheath thrombectomy device|
    US8795304B2|2009-06-18|2014-08-05|Cardiovascular Systems, Inc.|Atherectomy device, system and method having a bi-directional distal expandable ablation element|
    USD610761S1|2009-06-19|2010-02-23|Charles Gengler|Drain unclogger|
    WO2011038315A1|2009-09-28|2011-03-31|Zimmer, Inc.|Expandable intramedullary rod|
    JP5808792B2|2010-04-13|2015-11-10|ミビ・ニューロサイエンス・リミテッド・ライアビリティ・カンパニーＭｉｖｉ Ｎｅｕｒｏｓｃｉｅｎｃｅ ＬＬＣ|Acute stroke treatment device and system|
    US8365337B2|2010-07-09|2013-02-05|George Tash and Debra B. Tash, As Trustees of the Community Trust|Hand-operated drain snake with auger|
    US9220499B2|2010-10-28|2015-12-29|Covidien Lp|Wound closure device including barbed pins|
    USD649724S1|2010-12-09|2011-11-29|S.C. Johnson & Son, Inc.|Wand|
    US8597170B2|2011-01-05|2013-12-03|Thoratec Corporation|Catheter pump|
    DE102011011510A1|2011-02-17|2012-08-23|Acandis Gmbh & Co. Kg|Medical device for removing concrements and system with such a medical device|
    ES2871050T3|2011-03-09|2021-10-28|Neuravi Ltd|A clot retrieval device to remove the occlusive clot from a blood vessel|
    EP2763610B1|2011-10-04|2018-12-26|Angioworks Medical B.V.|Devices for percutaneous endarterectomy|
    JP6363957B2|2012-01-15|2018-07-25|トリティカム リミテッド|Device for removing occlusions in a biological tube|
    WO2013116529A1|2012-01-31|2013-08-08|The Trustees Of Columbia University In The City Of New York|Sampling catheter devices, methods, and systems|
    US9131988B2|2012-09-28|2015-09-15|Avent, Inc.|Self positioning tracheal tube clearance mechanism using skives|
    US8784434B2|2012-11-20|2014-07-22|Inceptus Medical, Inc.|Methods and apparatus for treating embolism|
    US9194114B2|2013-01-08|2015-11-24|Marvin Petry|Drain pipe cleaning device and method|
    US20160051261A1|2013-04-29|2016-02-25|Regenerative Sciences, Llc|Percutaneous Tendon-Muscle-Ligament Approximation Device|
    US9217243B2|2013-05-02|2015-12-22|Patrick Gwen|Drain cleaning tool|
    US9259237B2|2013-07-12|2016-02-16|Inceptus Medical, Llc|Methods and apparatus for treating pulmonary embolism|
    WO2016120864A2|2015-01-28|2016-08-04|Triticum Ltd.|Device and method for removing occlusions in a biological vessel|
    US10072405B2|2015-01-30|2018-09-11|Pf Waterworks Lp|Drain cleaning apparatus|US9402707B2|2008-07-22|2016-08-02|Neuravi Limited|Clot capture systems and associated methods|
    EP2629684B1|2010-10-22|2018-07-25|Neuravi Limited|Clot engagement and removal system|
    US11259824B2|2011-03-09|2022-03-01|Neuravi Limited|Clot retrieval device for removing occlusive clot from a blood vessel|
    ES2871050T3|2011-03-09|2021-10-28|Neuravi Ltd|A clot retrieval device to remove the occlusive clot from a blood vessel|
    JP6363957B2|2012-01-15|2018-07-25|トリティカム リミテッド|Device for removing occlusions in a biological tube|
    US11083475B2|2012-02-22|2021-08-10|Carter J. Kovarik|Medical device to remove an obstruction from a body lumen, vessel or organ|
    US10226266B2|2012-02-22|2019-03-12|Carter J. Kovarik|Selectively bendable remote gripping tool|
    US9901245B2|2012-02-22|2018-02-27|Carter J. Kovarik|Selectively bendable remote gripping tool|
    US9592066B2|2012-02-22|2017-03-14|Carter J. Kovarik|Selectively bendable remote gripping tool|
    US9832980B2|2012-02-22|2017-12-05|Carter J. Kovarik|Selectively bendable remote gripping tool|
    US9211132B2|2012-06-27|2015-12-15|MicoVention, Inc.|Obstruction removal system|
    US9642635B2|2013-03-13|2017-05-09|Neuravi Limited|Clot removal device|
    TR201820525T4|2013-03-14|2019-01-21|Neuravi Ltd|A clot removal device for removing an occlusive clot from a blood vessel.|
    US9433429B2|2013-03-14|2016-09-06|Neuravi Limited|Clot retrieval devices|
    TR201901830T4|2013-03-14|2019-03-21|Neuravi Ltd|Devices and methods for the removal of acute blockages from blood vessels.|
    USD780547S1|2013-08-08|2017-03-07|Carter J. Kovarik|Pick up device with flexible shaft portion|
    US10285720B2|2014-03-11|2019-05-14|Neuravi Limited|Clot retrieval system for removing occlusive clot from a blood vessel|
    WO2015189354A1|2014-06-13|2015-12-17|Neuravi Limited|Devices for removal of acute blockages from blood vessels|
    US10792056B2|2014-06-13|2020-10-06|Neuravi Limited|Devices and methods for removal of acute blockages from blood vessels|
    US10265086B2|2014-06-30|2019-04-23|Neuravi Limited|System for removing a clot from a blood vessel|
    US11253278B2|2014-11-26|2022-02-22|Neuravi Limited|Clot retrieval system for removing occlusive clot from a blood vessel|
    CN106999196B|2014-11-26|2020-07-28|尼尔拉维有限公司|Thrombus retrieval device for removing obstructive thrombus from blood vessel|
    US10617435B2|2014-11-26|2020-04-14|Neuravi Limited|Clot retrieval device for removing clot from a blood vessel|
    WO2016120864A2|2015-01-28|2016-08-04|Triticum Ltd.|Device and method for removing occlusions in a biological vessel|
    US11179170B2|2015-10-26|2021-11-23|Amnis Therapeutics Ltd|Systems for thrombectomy|
    CA3035706A1|2016-09-06|2018-03-15|Neuravi Limited|A clot retrieval device for removing occlusive clot from a blood vessel|
    US10842498B2|2018-09-13|2020-11-24|Neuravi Limited|Systems and methods of restoring perfusion to a vessel|
    US11253287B2|2018-10-04|2022-02-22|Neuravi Limited|Retrograde blood flow occlusion flushing device|
    CN109350179B|2018-12-06|2021-06-15|孙雷雷|Multi-stage inching circulating spot removing device for cardiology department|
    USD943225S1|2019-06-14|2022-02-08|Emerson Electric Co.|Clog removal tool|
    US10900211B1|2019-08-27|2021-01-26|Skip A Lei|Apparatus to scrape and extract drain clog debris|
    法律状态:
    2017-04-06| FGA| Letters patent sealed or granted (standard patent)|
    优先权:
    申请号 | 申请日 | 专利标题
    US201261586792P| true| 2012-01-15|2012-01-15||
    US61/586,792||2012-01-15||
    PCT/IL2013/050049|WO2013105099A2|2012-01-15|2013-01-15|Device and method for removing occlusions in a biological vessel|
    [返回顶部]